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In CAH, the enzyme block to cortisol production results in excessive production of a steroid precursor 17OH-progesterone (17OHP) which drives the production of excess adrenal androgens which in turn cause precocious puberty, short stature and infertility in children and adults with CAH

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These region-specific KP responses likely contribute to distinct depressive symptoms: altered amygdala activity may underlie increased fear and anxiety, while changes in the hippocampus and prefrontal cortex may disrupt cognition and emotional regulation

Ozempic is covered for Type 2 diabetes (E11.9) but not for weight loss under Medicare Part B as of this guide's publication