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A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency

Furthermore, -KG, which is produced from pyruvate in the TCA cycle, is known for its ability to bind to and remove ROS, a contributor to oxidative stress 24

In addition, genes, proteins and RNAs that inhibit ferroptosis may promote CRC development and progression

Chandler JD, Nichols DP, Nick JA et al (2013) Selective metabolism of hypothiocyanous acid by mammalian thioredoxin reductase promotes lung innate immunity and antioxidant defense