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A1AT is encoded by SERPINA1 locus, also known as PI locus, highly polymorphic with at least 100 allelic variants described and responsible for different A1AT serum levels and function

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Fagiolini A, Frank E, Turkin S, Houck PR, Soreca I, Kupfer DJ

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25 In Parkinsons Disease (PD), Acetyl-l-carnitine is a precursor to glutathione, increases dopamine transporter density, and in PD patients has shown corresponding improvements in clinical outcomes