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Drouin-OuelletJSt-AmourISaint-PierreMLamontagne-ProulxJKrizJBarkerRAet al

In cellular models, GSH depletion increases neuronal death in striatal neurons expressing mHTT, reinforcing the role of GSH-dependent redox imbalance in HD progression (400)

This is because over time oxygen in the air will oxidize reduced glutathione making it worse at eluting your protein from the beads

We also confirmed a decrease of extracellular adenosine accumulation from these activated CD73-deficient CD8 + T cells in vitro (Supplemental Figure 3E)