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Mechanistically, CB-839 elevates the levels of intracellular ROS, enhances the movement of Nrf2 into the nucleus, leading to an increase in uridine phosphorylase 1 (UPP1) mRNA expression

This is called antioxidant recycling, and it is crucial as we strive to protect the blueprints inside our cells DNA from the damaging effects of oxidative stress

This provokes some challenging symptoms, but suggests the treatment is addressing the root cause of the imbalance

The first step is to consult your healthcare provider so they can guide you to the best treatment option for your situation

Clinical, Cosmetic and Investigational Dermatology, 15, 18531862