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Current evidence suggests that cytosolic PGES (cPGES) and microsomal prostaglandin E synthase-2 (mPGES-2) are constitutively expressed in cells and are coupled with COX-1 and COX-1/-2, respectively (Murakami et al., 2 and, ideally, does not affect the formation of other housekeeping PGs (Koeberle et al., 2 in human epithelial cells, carcinoma cells (A549) and human whole blood treated with lip polysaccharides (LPS

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