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Because KLRG1 is widely used as a marker of highly activated, cytokine-producing ILC2s (66, 67), this finding supports the idea that melatonin drives a phenotypic transition from an activated, KLRG1 high effector state toward a more quiescent, KLRG1 low phenotype

However, if symptoms are severe, persistent, or associated with breathing difficulty, widespread rash, or swelling of the face or throat, immediate medical attention is required as these may indicate an allergic reaction

The clinical trial protocol used a gradual dose escalation to minimize GI side effects: Most users inject into the abdominal area, rotating sites with each injection