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Spinal stenosis is a more general narrowing of the spinal canal from age-related changes, often affecting multiple nerves at once and typically causing leg pain or weakness that worsens with standing and walking and improves with sitting or leaning forward

Fibromyalgia: family clustering and sensory urgency with early onset indicate genetic predisposition and thus a true disease

Moreover, adipose tissue macrophages in obesity adopt a pro-inflammatory M1 phenotype, further amplifying systemic immune activation, whereas weight reduction favors a switch toward an anti-inflammatory M2 phenotype [39]

These imbalances were seen to be related to both the increase of pro-inflammatory cytokines (TNF-alpha and IL6) and to the alteration of mechanisms that prevent bacterial translocation, testifying an important role of these microbiological alterations in the evolution of liver disease [44]

"These unclear, opaque notices really distort the scientific literature," he says