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The AMPK pathway regulates fat metabolism through lipase catalysis, while the PI3K/AKT signaling pathway alleviates insulin resistance, activates the AMPK signaling pathway, directly inhibits inflammatory factors, thereby inhibiting inflammation, and regulates the gut by improving the composition, proportion, and diversity of intestinal microbes

Positive PDPN and THY1 expression characterize three sublining FLS subsets: (1) perivascular CD34 + THY1 + HLA-DR low , (2) pro-inflammatory THY1 + CD34 HLA-DR high , and (3) THY1 + CD34 Dickkopf (DKK)3 + HLA-DR low ( Figure 3 ) (55, 60)

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