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A comprehensive review in Nature Reviews Disease Primers described B12 deficiency as a significant and underrecognized public health concern, particularly among older adults, individuals with gastrointestinal conditions, and those following plant-based diets (Green et al., Nat Rev Dis Primers , 2017)

DDR signaling involves the release of signaling and repair proteins, such as -H2AX and phosphorylated p53, which accumulate at DSB sites to form DNA damage foci [18]

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