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The most commonly reported side effects in clinical trials include: Nausea Vomiting Diarrhea Constipation Most of these symptoms were mild to moderate and tended to improve over time as the body adjusted to the medication, especially when doses were increased gradually

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Systemic effects less commonly include mild dizziness or lightheadedness (may be copper-related), temporary nausea or headache (typically resolves within hours), mild fatigue (rare, reported with higher doses), and transient flu-like symptoms (very rare, may relate to systemic inflammatory response)

Helps Regulate Inflammation

Jun 07, 2026, 17:30 ET CagriSema, a once-weekly investigational treatment that combines a novel amylin analog with a GLP-1 receptor agonist (RA), achieved significant reductions in HbA 1c and bodyweight versus comparators across three phase 3 trials in adults with type 2 diabetes (T2D) 1-3 Data from the REIMAGINE clinical development program, a series of phase 3 trials evaluating once-weekly CagriSema in adults with T2D across various stages of their disease, were presented at an ADA symposium 1-3 Novo Nordisk continues to demonstrate pioneering leadership and scientific innovation through advancing diabetes research PLAINSBORO, N.J