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Lancet Neurol 15(5):455532

doi: 10.1615/JEnvironPatholToxicolOncol.v28.i1 161 StejskalVDDanersundALindvallAHudecekRNordmanVYaqobAet al

[DOI] [PubMed] [Google Scholar] 120.Lushchak VI

Under normal physiological conditions, about 3% of cytosolic glucose is processed via the polyol pathway, however, at higher concentrations of glucose, about 30% of the glucose enters the polyol pathway which makes it important in disposing of the glucose molecules and subsequent conversion to sorbitol [128]

This situation would lead to a self-perpetuating cycle, in which the free radicals generated would induce GSH depletion, thus increasing oxidative stress that would reduce antioxidant enzyme levels, which would further reduce GSH synthesis