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Neutrophils also produce ROS that can promote inflammatory cell migration to clear foreign materials and pathogens but this also results in host tissue damage (Mittal et al., 2014)

Mitochondrial complex II can generate ROS when the functions of complex I and III are inhibited, and ROS may be produced via the electron transfer from succinate or in the reverse direction when electrons are provided from a reduced ubiquinone pool [118]

However, the buildup of WES and WGS data in the human population and the systematic use of trio sequencing will possibly increase the diagnostic yield in unexplained conditions (79)