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doi: 10.1016/j.addr.2012.10.002

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Precautions Avoid use in known vitamin hypersensitivity cases Use carefully in patients with kidney or liver impairment Pregnant or breastfeeding women should take medical advice Always follow the prescribed dosage strictly Store in a cool, dry place away from sunlight Following precautions ensures safe therapy and better clinical outcomes

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Thus, all three of the main UA transporters may contribute to the brain concentrations of UA through their action at the blood-brain barrier, although ABCG2 is thought to have the greatest effect, probably acting to remove UA from brain to blood 45