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While some disorders result in a normal life expectancy, those that affect blood vessels may result in a shorter life expectancy

Greer 2007) that the US Food and Drug Administration (FDA) approved a large-scale clinical trialthe Targeting Aging with Metformin (TAME) trialto test its effects on biological aging (AFAR 2016)

Extending the findings from the UK cohort study, additional real-world data derived from the Taiwan National Health Insurance Databasewhich encompasses Asian populations characterized by lower gallstone prevalence, low-fat and high-fiber dietary patterns, and lower body mass indexalso documented an elevated risk of biliary-related diseases linked to GLP-1 RAs compared with SGLT-2 inhibitors [36]