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This reaction neutralizes the highly reactive superoxide radical, converting it into hydrogen peroxide, which can then be processed by other antioxidant enzymes like catalase and glutathione peroxidase

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This type of defect is particularly challenging because the gap is too large for the body to bridge through normal healing processes alone

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183 The recruitment of these proteins leads to the formation of the death-inducing signaling complex, which induces the internalization of the receptor, and apoptotic reactions ensure via either caspase- or mitochondrial-mediated cascades