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2012;302:G1171G1179

Steps for tick removal Don non-latex gloves Clean the affected area with a povidone iodine swab (3 times in a circular motion) Use a magnifying glass to locate the head of the tick Hold the tweezers close to the skin surface grasping the end (head) of the tick Use the tweezers to pull upward with a steady motion (avoid jerking) to remove the tick Once the tick is removed, clean the surface with an alcohol pad Assess the area to ensure the entire tick was removed Place the live tick in alcohol to kill it or flush it down a toilet Video link kaltura.com/tiny/rxrsh : This video is the intellectual property of the University of Alabama at Birmingham and cannot be shared without request of a license (please contact [email protected])

It is also worth noting that animal model studies have illustrated a mechanistic contribution of microbial TMA and TMAO generation to enhanced development of atherosclerosis, platelet reactivity and thrombosis, and both impairment in renal function and fibrosis, as well as adverse ventricular remodeling and heart failure (refs

Eur J Endocrinol (2012) 166:24753

Some metabolic enzymes, such as succinate dehydrogenase (SDH), fumarate hydratase (FH), IDH and pyruvate kinase 2 (PKM2) are likely to activate HIF-1 pathway by stabilizing HIF-1, therefore enhancing cancer metastasis (258)