acetaminophen overdose napqi glutathione mechanism authoritative source metabolism. Acetaminophen is metabolized primarily by sulfation and glucuronidation. However, it can also be oxidized by CYPs to form NAPQI. can then interact with cellular macromolecules, resulting in toxicity, or it can be detoxified Xia & He Publishing
Xia & He Publishing The molecular mechanisms of acetaminophen induced hepatotoxicity and its potential therapeutic targets PMC Full article: Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease Mechanisms of acetaminophen induced liver injury and its implications for therapeutic interventions PMC Acetaminophen Induced Hepatotoxicity: a Comprehensive Update
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