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Malik and Dichgans, 2018

What appears to be consistent in the above triggers of CFS is that they initiate excessive amounts of inflammation and oxidative stress, which has a direct impact on mitochondrial function

Most of the hives appear minutes to and hour after being exposed to the trigger

Inhibition of CYP51A1 with ketoconazole has demonstrated diverse biological effects: it rescued EGFR degradation in A431 carcinoma cells by blocking sterol metabolism upstream of MSMO1, and reduced inflammatory signaling and cytokine release in mouse macrophages, ultimately improving survival in a model of endotoxic shock