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One route involves the hydrolysis of cytoplasmic CE by neutral cholesterol esterase and the resulting free cholesterol is mobilized away from the ACAT pool (72,73) and made available for efflux via ABCA1, ABCG1, SR-BI, and aqueous diffusion (Figure 2)

Li Qian, Wenjun Wang, Yan Zhou, Jianxin Ma

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Given that the majority of patients with breast cancer predominantly exhibited POI during chemotherapy, and considering that there were differences in the internal microenvironment induced by breast cancer and the normal internal microenvironment, we simulated the dosage and duration of chemotherapy to establish a breast cancer mouse model of POI 41,42,43