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Studying the glutathione redox imbalance and mitochondrial abnormalities in embryonic AS NPCs provides an essential insight into the involvement of UBE3A in early neural development, information that can serve as a powerful avenue towards a broader view of AS pathogenesis

The desensitization may involve decreased expression of the proteins STIM2, Orai1, and Orai3 which support SOCE mechanism

Furthermore, DCs can produce a variety of immune stimulating factors, such as cytokines and chemokines, which induce DCs and NK cells to reach inflammatory sites (211), as well as induce the activation of tumour-specific T cells (212)

However, plasma samples are low in glutathione and may be difficult to measure depending on the sample

LiYLiuCXinLLiuCCaoJYueZet al