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Pharmacologically induced depletion of resident microglia with tamoxifen and diphtheria toxin prior to the induction of ischemic stroke in a mouse model resulted in a decreased infarct volume and levels of pro-inflammatory factors (Li et al., 2021)

Interestingly, TZDs showed effects on suppressing ferroptosis by selectively inhibiting ACSL4 15,273 in breast cancer cell lines and reduce mortality due to acute renal failure in kidney-specific Gpx4 knockout mice