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Science 344 , 1252304 (2014)

Glutathione works by neutralizing free radicals directly and by supporting the bodys natural detoxification pathways, particularly in the liver

They were originally discovered in bone marrow but were later found in many other adult tissues, such as adipose tissue and placenta

Valsartan was without grossly observable adverse effects at single oral doses up to 2000 mg/kg in rats and up to 1000 mg/kg in marmosets, except for the salivation and diarrhea in the rat and vomiting in the marmoset at the highest dose (60 and 37 times, respectively, the MRHD on a mg/m2 basis) (Calculations assume an oral dose of 320 mg/day and a 60 kg patient)

10.1016/0014-5793(95)01185-H 134 MeunierJ