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(2) Summing the individual manufacturer's total billing units sold during the applicable calendar quarter (for all NDCs of the manufacturer assigned to the billing and payment code)

Whereas M2 macrophages can exert cancer-promoting effects in several ways, such as directly promoting cancer cell metastasis (190), promoting angiogenesis (191), and inhibiting tumor-killer cell activity (192), this suggests that bilirubin may promote cancer through this mechanism