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Proc Natl Acad Sci USA 89 : 69836987 Oscarsson J et al

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Semaglutide was initiated at 0.25 mg per week for the first 4 weeks via a pre-filled pen injector, escalating in a fixed-dose regimen every 4 weeks to reach the maintenance dose of 2.4 mg by week 16 (lower maintenance doses were permitted if participants were unable to tolerate 2.4 mg) (Extended Data Fig

It is important to note that while this product is available for purchase without prescription, users should still familiarize themselves with proper injection techniques or seek assistance if uncomfortable with self-administration