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The route of estrogen replacement is an important influence on GH requirement and those on oral estrogen are clearly more GH resistant than women using transdermal preparations (373,374)

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Tendon-derived stem cells (TDSCs) are present in tendons and exhibit enhanced chondrogenic and tendinogenic differentiation after tendon damage, forming tendon-like-bone-like tissues and enhancing tissue repair [30,31,32,33,34,35]

In such cases, not only do these treatments amplify neurotransmitter receptor signaling, but they may have other possible effects such as reduction in depression, neuroprotection, and stimulation of appetiteall effects that may relate to the effects on GHSR alone and not the dimer

Adv Exp Med Biol 136, B86579