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The study had three phases: a 2.5 week, randomized, double-blind, placebo-controlled crossover phase in which each man received in-office injections of placebo or 2.5 mcg, 5 mcg, 7.5 mcg, or 10 mcg of CAVERJECT

Constipation is managed with adequate fiber, hydration, and if needed, gentle fiber supplements

Intranasal bioavailability is estimated at 60-70%, with onset of anxiolytic effects within 5-15 minutes

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