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Glutathione (thathion) is one of the most important peptides synthesized in the human body

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The demonstrated importance of protecting the terminals to pharmacokinetic characteristics suggests numerous additional synthetic approaches that may be applicable including the insertion of non-peptide linkages (see Sardinia et al., 1994) between the first and second amino acids, the replacement of the N-terminal amino acid with a non- amino acid, and N-terminal acylation

Because of their shared Ser20 phosphorylation mechanism, both ATM kinase and ATR kinase mediate the stabilization of human p53 in response to infrared- and ultraviolet-induced DNA damage (Chehab et al., 1999)