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In some embodiments, the amount of thermoreversible polymer (e.g., pluronic F127) in any formulation described herein is about 12% of the total weight of the formulation

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In some embodiments, the thickened liquid formulation or composition also has an immediate or rapid release component for delivery of the therapeutic agent to the desired target site

Common reasons Dose too low - may need to increase to therapeutic levels (2.4mg or higher) Not enough time - meaningful results typically take 8-12 weeks at adequate doses Calorie-dense liquid calories bypassing satiety signals - watch smoothies, alcohol, sugary drinks Eating through fullness signals - pay attention to your body's cues Inconsistent dosing schedule - must be same day each week for optimal levels Unrealistic expectations - 1-2 lbs per week is healthy, sustainable weight loss Key Research [1]"Once-weekly cagrilintide for weight management in people with overweight and obesity" Lau DCW et al., 2021 Finding: Phase 2 trial showed cagrilintide at 4.5mg achieved 10.8% weight loss versus 3% with placebo over 26 weeks in 706 participants

In another embodiment, the methyl paraben is at a concentration of about 0.05% to about 1.0%, about 0.1% to about 0.2%