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Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies

Key neurological warning signs include: Progressive numbness that typically starts in your feet and hands, gradually spreading upward through your limbs Coordination difficulties affecting both fine motor skills in your hands and broader balance issues while walking Changes in reflex responses, particularly positive Babinski signs and diminished deep tendon reflexes in your lower extremities These symptoms often present alongside psychiatric manifestations like irritability and apathy