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Pulsatile GH preservation: The peptide maintained the natural pulsatile pattern of GH release rather than producing a flat, continuous elevation

The animals were maintained in clean plastic crates (three animals per crate) and given a rat pelleted conventional food supplemented with water ad libitum throughout the experimental phase

(-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol hydrochloride (tapentadol HCl): a novel mu-opioid receptor agonist/norepinephrine reuptake inhibitor with broad-spectrum analgesic properties