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Description

the keyword here is regularity, not frequency

Escalate: Double the dose every 2 weeks (0.6 1.2 2.4 4.5 mg) as tolerated

Apixaban's FDA label explicitly warns against co-administration with strong dual CYP3A4/P-gp inhibitors such as ketoconazole, itraconazole, and ritonavir, and strong dual inducers like rifampin and carbamazepine (FDA Eliquis Prescribing Information)