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Its first clinical definition was given in 1817 by Thomas Bateman, who referred to it as porrigo decalvans. The definition in its modern sense began to take shape a few decades later [27]

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1 Introduction Numerous scientific studies have confirmed the role of diet in maintaining the proper functioning of the human body and in the prevention and treatment of various diseases, including obesity, diabetes, and cardiovascular disease ( 2 History of the ketogenic diet The earliest reports on the use of a low-carbohydrate diet to reduce the severity of symptoms, especially epileptic seizures, date back to antiquity ( In 1911, French doctors Guelpe and Marie published the first scientific report on the benefits of intermittent fasting in epilepsy ( In 1925, Dr

Accumulating evidence has indicated that lysosomal damage is closely related to the development of apoptosis 6,95 , necroptosis 8,10 , pyroptosis 11 , and ferroptosis 13,96 (Fig

Timing is a planning convention here, not a medical instruction