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Simple Combinations of Lineage-Determining Transcription Factors Prime Cis-Regulatory Elements Required for Macrophage and B Cell Identities

To validate our findings, we used atp-3 RNAi, a positive control, which is known to cause mitochondrial fragmentation due to ATP synthase dysfunction 85,86

To confirm whether clofazimine also inhibits post-entry steps of viral replication, we evaluated the effect of clofazimine on the production of viral RNA by electroporating in vitro-transcribed viral RNA into Vero E6 cells, which bypasses clofazimine-mediated inhibition on the entry process and directly measures RNA synthesis (Extended Data Fig

Possible reasons may include the difficulty in distinguishing the effects of endogenous versus exogenous lactate, as well as challenges in translating findings into broad clinical applications

The patient was a young gay man who had been travelling to the USA and who was consulting Dr