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AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes

Mechanosensitive proteins include focal adhesion proteins, cell-cell adhesion, integrin and ECM proteins, receptor tyrosine kinases, G-protein-coupled receptors, cytoskeletal proteins and, importantly, ion channels that are activated by minute changes in membrane curvature and stretch in the absence of chemical ligands (124-126)