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The development of curcumin complexes enables the development of technetium(I)-99m-based tools with potential diagnostic or therapeutic applications in treating Alzheimers disease (Triantis et al., 2013)

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Finally, we investigated whether a decreased leakage of mitochondrial ROS was due to direct antioxidant properties of tested therapeutics, or whether these compounds influence the ROS leakage by modulation of activity and efficiency of mitochondrial respiratory chain.25 We measured mitochondrial respiration of the cells maintained in the complete medium in a basal state and during maximal stimulation with an uncoupling agent FCCP, and basal proton leakage during inhibition of Complex V with oligomycin

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This is exemplified by variable responsiveness to therapeutics such as those targeting IL-23/IL-17 signalling, and other consistently observed differences in clinical course including progression and severity both within and between SpAs subtypes