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Thus, multi-step isoleucine catabolism enzymes, including the BCKDH complex, are present and active in the nuclei of PDA cells

Although small-molecule PHGDH inhibitors effectively suppress tumor proliferation in preclinical models [52, 53], their therapeutic index may be limited by the essential physiological role of de novo serine synthesis in the central nervous system [54]

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Neurosurgery: Advancing Brain and Spine Health By Bob Berendsen February 5, 2025 Neurosurgery is a specialized field of medicine focused on the diagnosis and treatment of disorders affecting the spinal cord, nerves, and peripheral nervous system

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