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Research has studied its effects on adipocyte size, fat mass regulation, and systemic metabolic activity in preclinical models

non-pregnant females) on metformin therapy ( 1000 mg/day) for more than 4 months and have vitamin B12 level 200 pg/mL)

however, this vitamin is not toxic in higher levels than have been prescribed , so toxicity concerns aren't something you have to worry about when using the supplement to treat a deficiency