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Interaction with Medications: May interact adversely with other medications, leading to dangerous side effects

This tri-receptor activity profile is what separates it from earlier compounds like semaglutide (GLP-1 only) and tirzepatide (GLP-1/GIP), and is the basis for the significant fat loss results observed in Phase 2 clinical trials

Since semaglutide already impairs the normal B12 absorption pathway, using a form that requires fewer metabolic steps to become active reduces the total burden on an already stressed system