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And finally, subunit vaccines can constitute viral proteins incorporated in synthetic nanomaterials, protein cages and VLPs, which serve as adjuvants and/or delivery vehicles, in addition to conferring other benefits inherent to each nanocarrier platform 55,56,57

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The default independent filtering function was replaced with independent hypotheses weighing from the IHW package ( v1.22.0 ) to increase statistical power by adjusting p values based on the mean expression level of each gene which was followed with multiple testing correction using the BenjaminiHochberg adjustment [35]

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