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This research was supported by the Intramural Research Program of the NIH/NINDS, an NIH Directors New Innovator Award (NIH/ NIGMS DP2 GM119139 to M.K.), NIH/NIA grants (R01 AG062359 and R56 AG057528 to M.K., F30 AG066418 to K.L.), the NINDS Tau Center Without Walls (NIH/NINDS U54 NS100717 to M.K.), an Allen Distinguished Investigator Award to M.K