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Before performing in vivo experiments, we assessed the efficacy of GCEE supplementation on cultured cortical neurons, finding that it inhibited the depletion of GSH levels in neurons treated with the GCL inhibitor BSO (Fig

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developed supramolecular prodrug nanoassemblies (SPNA) for reactive nitrogen species (RNS)-enhanced chemotherapy (Figure 3D) (Figures 3E, F), thereby generating highly toxic peroxynitrite anion (ONOO )