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Dedicated studies comparing the combination to each peptide alone are still needed to confirm any added effect

PMID: 87 TalarekSListosJBarrecaDTelloneESuredaANabaviSFet al

This regional microbiota-metabolite-brain axis effect directly affects cognitive function: the continuous activation of microglia leads to abnormal synaptic pruning and neuronal damage

Given that GSSG was significantly accumulated in the A2ARi-treated activated CD8 + T cells (Figure 3H), we hypothesized that the T cell ferroptosis induced by A2ARi could be due to the enhanced GSH usage and subsequent increased GSSG accumulation