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on 24 patients with generalized vitiligo and 20 healthy controls found statistically significant higher levels of superoxide dismutase activity in erythrocytes, serum MDA, and nitric oxide (NO) and statistically significant lower levels of glutathione and glutathione peroxidase in the patients of vitiligo compared to the controls.[] Secondary to the oxidative stress, the polyunsaturated fatty acids undergo peroxidation resulting in formation of free radicals

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TAM acts on brain ER, ER, and the transmembrane receptor GPR30 (Gonzalez et al., 2016)

PRP and BMAC naturally boost PGE, which indirectly reduces 15-PGDH activity similar to what the drug aims to accomplish