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The rationale is further supported by several studies that demonstrated that the human gut microbiome is a major determinant of plasma metabolome, potentially playing a more dominant role than genetics

Brancaccio, P., Lippi, G

Sleep Med 2020;75:263-75

[DOI] [PMC free article] [PubMed] [Google Scholar] 94.Coffey EE, Beckel JM, Laties AM & Mitchell CH Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimers disease-linked presenilin 1 A246E mutation can be reversed with cAMP