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By addressing multiple inputs that influence growth hormone and IGF-1 activity, the stack reflects a systems-based approach inspired by endocrine research

Furthermore, alpha-keto acid dehydrogenase complexes, including pyruvate dehydrogenase complex, are localized near the inner mitochondrial membrane-bound complex I of the mitochondrial respiratory chain, thus suggesting direct coupling of oxidation of specific alpha-keto acids and generation of NADH for transfer of electrons to the mitochondrial respiratory chain via complex I (58)

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