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del Rio, B., Seegers, J

Histopathological hallmarks include hepatic swelling, vacuolar degeneration, and necrosis, while clinical markers feature elevated serum transaminases (ALT, AST) and bilirubin, alongside reduced albumin, indicating compromised liver function ( TNF- , IL-1 , IL-6 , and IL-8 , alongside anti-inflammatory mediators like IL-10 ( The zebrafish model has emerged as a powerful system for deconstructing this complexity (Table 3), owing to its high evolutionary conservation in liver morphology and function, including a well-characterized suite of CYP450 enzymes and a drug metabolism system that parallels human pathways ( in vivo DILI studies in larvae

Nature 593 (7860), 586590

[DOI] [PubMed] [Google Scholar] 44

Here's what else can affect testosterone decline: Poor sleep quality and sleep apnea Chronic illnesses and stress Medications, particularly opioids Previous use of anabolic steroids High alcohol consumption and smoking Low testosterone isn't just about getting older