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These enzymes utilize glutathione to conjugate and detoxify drugs and other xenobiotics

10.1016/j.ctim.2019.02.017 Complement

doi: 10.1146/annurev-ento-022024-015159

Manganese superoxide dismutase (MnSOD) converts O 2 to H 2 O 2 , which can then be reduced to H 2 O by catalase and/or an antioxidative system comprised of gluthione, gluthathione peroxidases (Gpx), peroxiredoxins (Prx), and thioredoxins (Trx), dependent on the redox status and availability of reducing equivalents within mitochondria [5859]