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However, epigenetic modifications regulate tumor cuproptosis and disulfidptosis by modulating the expression of cuproptosis and disulfidptosis-associated lncRNAs

55 On the other hand, pioglitazone, a peroxisome proliferator-activated receptor (PPAR)- agonist, is another antidiabetic drug that could interferes with the glutaminolysis-ammonia-urea cycle axis by restricting the conversion of glutamine to glutamate by reducing the expression of GLS1, the rate-limiting enzyme