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Concerns persist about DHA-related cytotoxicity, genotoxicity, and systemic absorption

It was shown through c-Fos immunoreactivity that systemic introduction of Bremelanotide has been shown to activate neurons found in the hypothalamus

However, apomorphines efficacy was modest, and it tended to cause a lot of nausea (because it stimulates dopamine receptors indiscriminately, including in the chemoreceptor trigger zone)